Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, Benp is a useful agent for studying the functions of the Arp2/3 complex in cancer cell migration and metastasis.
|
30710516 |
2019 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The biologic and clinical significance of ANGPTL2 remains unknown in human cancer.
|
25294915 |
2014 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, ANGPTL2 has been found to be upregulated in some types of cancers and is considered to be a tumor promoter.
|
28247845 |
2017 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The Arp2/3 Regulatory System and Its Deregulation in Cancer.
|
29212790 |
2018 |
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of ANGPTL2 in highly malignant gastric cancer cell lines BGC823 and PAMC82 was significantly higher than in low malignancy gastric cancer cell lines N87 and SGC7901.
|
28058016 |
2016 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Angiopoietin-like 2 (ANGPTL2), a secreted protein which belongs to the angiopoietin (ANGPTL) family, was reported to be involved in the regulation of several different type of cancer cell proliferation and metastasis.
|
31384179 |
2019 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3.
|
26370503 |
2015 |
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Angiopoietin-like protein 2 (ANGPTL2) is associated with tumor progression while dysregulation of its expression has been observed in various types of cancer.
|
25174582 |
2014 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Arp2/3 specificity may thus provide diagnostic and therapeutic opportunities in cancer.
|
30971746 |
2019 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunofluorescence and western blotting showed a positive correlation between the expression of Arp2/3 and the malignancy of glioma specimens (r=0.686, P=0.02) and confocal microscopy demonstrated localization of the Arp2/3 complex in lamellipodia of glioma cells.
|
23969835 |
2013 |
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Spearman's rank correlation analysis showed a significant correlation between the <i>ANGPTL2</i> mRNA level and the degree of vascular invasion of cancer (r=0.66; P=0.01).
|
30655796 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In order to determine whether the same mechanism correlates with liver metastasis from colorectal cancer, paired mirror sections of 154 cancer specimens (29 cases with liver metastasis and 125 cases without liver metastasis in which T factor, gender, primary tumor site, and age at operation were matched) were examined immunohistochemically for the localization of Arp2 and WAVE2.
|
17459058 |
2007 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cortactin is an actin-related protein 2/3 (Arp2/3) complex-activating and filamentous (F)-actin-binding protein that is implicated in tumor cell motility and metastasis, partially by its ability to become tyrosine phosphorylated.
|
16912177 |
2006 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These cells grew slowly and were expanded over a period of 3 years and have maintained characteristics consistent with those of both the original ASPS tumor from the patient and the xenograft tumor including (1) presence of the alveolar soft part locus-transcription factor E3 type 1 fusion transcript and nuclear expression of the alveolar soft part locus-transcription factor E3 type 1 fusion protein; (2) maintenance of the t(X;17)(p11;q25) translocation characteristic of ASPS; and (3) expression of upregulated ASPS transcripts involved in angiogenesis (ANGPTL2, HIF-1-α, MDK, c-MET, VEGF, and TIMP-2), cell proliferation (PRL, PCSK1), metastasis (ADAM9), as well as the transcription factor BHLHB3 and the muscle-specific transcripts TRIM63 and ITGβ1BP3.
|
21552147 |
2011 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, we observed a correlation between higher ANGPTL2 expression in primary unresectable tumors from colorectal cancer patients who underwent chemotherapy with a lower objective response rate.
|
25287946 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It was found that the concentration of serum ANGPTL2 was significantly higher in pancreatic cancer patients and tumor stage 0-I patients than in healthy individuals (5.84 ± 1.82 ng/mL vs 3.61 ± 0.64 ng/mL; <i>P</i> < 0.001) (5.68 ± 0.79 ng/mL vs 3.61 ± 0.64 ng/mL; <i>P</i> = 0.010).
|
30588259 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ERK1/2 phosphorylation of cortactin has emerged as an important positive regulatory modification, enabling cortactin to bind and activate the Arp2/3 regulator neuronal Wiskott-Aldrich syndrome protein (N-WASp), promoting actin polymerization and enhancing tumor cell movement.
|
21079800 |
2010 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, Angptl2 promoted OS tumor growth in vivo tumor xenografts.
|
31737187 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of ANGPTL2 in tumor cells is associated with tumor progression and has been recognized in lung, breast, colon, and gastric cancer.
|
25564164 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, the combination of Ad-HARPΔ111-136 and radiation therapy resulted in a striking inhibition (92%) of the growth of U87MG xenografts, resulting from the potent effect on tumor angiogenesis and tumor cell apoptosis as determined by TUNEL analysis.
|
21109939 |
2011 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intravasation mediated by the integrin α5β1, p38 mitogen-activated protein kinase, and matrix metalloproteinases.
|
24448647 |
2014 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Arp2 expression in BUC tissues was associated with tumor size, tumor multiplicity, tumor stage, tumor grade, and lymph node metastasis (<i>P</i> < 0.05).
|
29593429 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, ANGPTL2 activates dendritic cells through PIR-B-NOTCH signaling and enhances tumor vaccine efficacy.
|
31727773 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, the tumorigenesis assay showed that ANGPTL2 knockdown inhibited glioma tumor growth in vivo.
|
28247845 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that tumor cell-derived ANGPTL2 may increase bone metastasis by enhancing breast tumor cell responsiveness to CXCL12 signaling through up-regulation of tumor cell CXCR4 expression.
|
25773070 |
2015 |